Omezole

Omeprazole

Omezole (Omeprazole), a substituted benzimidazole, is an inhibitor of gastric acid secretion. Omeprazole inhibits secretion of gastric acid by blocking the hydrogen-potassium-adenosine triphosphatase enzyme  system, the so-called `proton pump’ of the gastric parietal cell. It is an effective treatment for gastric and duodenal ulcers and particularly for erosive reflux oesophagitis. Orally administered Omezole  is absorbed rapidly but to variable extent. Following absorption Omezole is almost completely metabolized and rapidly eliminated mostly in the urine. Although the elimination half-life  from plasma is short, being reported to be 0.5 to 1.5 hours, its duration of action with regard to inhibition of acid secretion is much longer and  it is suggested that its distribution to the tissues  particularly to the  gastric parietal cells accounts to for this action. Omezole is highly bound (about 95%) to plasma proteins.

COMPOSITION

Omezole Capsules: Each capsule contains  Omeprazole BP 20 mg as enteric coated granules.