Amlodipine and Atenolol
Calock Plus is a fixed dose combination of Amlodipine and Atenolol. Amlodipine is a dihydropyridine calcium antagonist that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle; It has a greater effect on vascular smooth muscle than on cardiac muscle. Amlodipine is a peripheral vasodilator that acts directly on vascular smooth muscle to cause a reduction in peripheral vascular resistance and reduction in blood pressure. Amlodipine reduces tone, decreases coronary vasoreactivity and lowers cardiac demand by reducing after load. Atenolol is a cardio selective beta-blocker. The cardio-selectivity is dose-related. It lowers blood pressure by reducing cardiac output, plasma renin and sympathetic outflow of CNS. Atenolol also causes a reduction in myocardial oxygen demand by virtue of its negative inotropic and negative chronotropic effects.
*Patients with essential hypertension
*Patients with angina pectoris and hypertension as co-existing diseases
*In post Myocardial Infarction patients
*In patients with refractory angina pectoris where nitrate therapy has failed.